Attack of the Killer Shrews (1959)
A desperate group are trapped on a remote island by a hurricane. On the island, a doctor works to make humans half-size. This, apparently, will reduce world hunger as smaller humans would presumably eat less. Unfortunately, his experiments have also created some giant, venomous shrews. As the shrews run out of smaller animals to eat, they move in on the people in the house. Starring James Best of Dukes of Hazard, who used to play Sheriff Roscoe P. Coltrain.