George Milton (Gary Sinise) is in a train boxcar, reminiscing upon the events that have just happened. He thinks back to when he and his companion Lennie Small (John Malkovich) are fleeing from their previous employment in Weed. They were run out of town after Lennie was accused of attempted rape when he touched a young woman’s behind (prompted by his love of stroking soft things). Then George thinks of the events that have recently happened and make up the movie, taking place during the Great Depression .wiki

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